Quentin and Robert’s mini-review of our lab’s recent work showing that essential coenzymes (ADP, NADH, PLP) exhibit nonenzymatic reactivity in the presence of metal ions is published in Science Advances. Collectively, the work gives insight into the role coenzymes might have played in a pre-enzymatic metabolism. Congrats to all!
Valentyn’s paper on tetrahydroquinoline synthesis starting from N-benzylhydroxylamines has been accepted for publication in Chemical Communications. Congrats also to undergraduate author Daniella for her contributions!
Cyprien’s paper on developing a method for measuring kinetics of chemical reactions under vibrational strong coupling was accepted for publication in Angewandte Chemie. Congrats!
Valentyn’s paper on a styrene diamination that installs an NH2 group alongside nearly any nitrogen nucleophile has been accepted for publication in Angewandte Chemie. Congrats!
Robert’s paper on the metal-dependent nonenzymatic reaction of NADH with keto acids has been accepted for publication in Chem. Our second paper in that journal in 2024. Congrats!
The latest from our collaboration with the Ebbesen group on Vibrational Strong Coupling is published in Angewandte Chemie. We disclose an optical cavity that can fit in a standard NMR tube, allowing to directly observe the effects of VSC by NMR. The technique is showcased by using Schreiner’s molecular balance for London dispersion forces to probe how those forces change under VSC. Congrats to Bianca, Maciej and all the other authors!
Maciej’s invited review on difunctionalization processes enabled by HFIP has appeared in ACS Org. Inorg. Chem. Au. Congrats!
Harpreet, Sophia, and Emilie’s paper on an H2-driven Ni-catalyzed reaction network that can make new ketoacids through reductive aldol chemistry and enable their reductive amination to amino acids in one pot without human intervention has been accepted for publication in Chem. Many thanks to our collaborators in Germany (Dr. Harun Tüysuz, Dr. Youngsong Dong and Prof. Bill Martin). Congrats to all!
Emilie’s side project on the incorporation of sulfoximines into the aza-Piancatelli reaction has been published in Organic Letters. Our summer student from Heidelberg, Milena Wiegand, contributed to the project during her stay. Congrats to all!
Joris and Robert’s paper on the mechanism of the nonenzymatic phosphorylation of pyruvate to phosphoenolpyruvate is published in Chemical Science. The results suggest that a single phosphorylation mechanism could have been sufficient to initiate a self-organized metabolic network. Congrats to all!
The Moran Research Group 