Independent Publications:

52. Chevallot-Beroux, E.#; Gorges, J.#; Moran, J.* “Energy conservation via thioesters in a non-enzymatic metabolism-like reaction network” ChemRxiv. (# = contributed equally)

51. Sau, A.; Nagarajan, K.; Patrahau, B.; Lethuillier-Karl, L.; Vergauwe,R. M.; Thomas, A.; Moran, J.*; Genet, C.*; Ebbesen, T. W.* “Modifying Woodward-Hoffmann stereoselectivity under vibrational strong coupling” Angew. Chem. Int. Ed. 202160doi: 10.1002/anie.20202013465.

50. Muchowska, K. B.; Moran, J.* “Peptide synthesis at the origin of lifeScience 2020, 370, 767-768 (Perspective).

49. Isnard, R.; Moran, J.* “À l’origine de la vie : les premières formes de métabolismes sur Terre” L’Actualité Chimique 2020, 455, 24-30. (not peer-reviewed) (green open access)

48. Pozhydaiev, V.; Power, M.; Gandon, V.; Moran, J.* Leboeuf, D.* “Exploiting Hexafluoroisopropanol (HFIP) in Lewis and Brønsted Acid-Catalyzed Reactions” Chem. Commun. 2020, 56, 11548-11564 (feature article). (green open access)

47. Muchowska, K. B.*; Varma, S. J.; Moran, J.* “Nonenzymatic Metabolic Reactions and Life’s Origins” Chem. Rev. 2020, 120, 7708-7744. (green open access)

46. Montalvo-Acosta, J. J.; Dryzhakov, M.; Richmond, E.; Cecchini, M.*; Moran, J.* “A Supramolecular Model for the Co-Catalytic Role of Nitro Compounds in Brønsted Acid Catalyzed ReactionsChem. Eur. J. 2020, 26, 10976-10980 (invited manuscript for the EuChemS special issue). (green open access)


45. Zhang, S.; Leboeuf, D.; Moran, J.* “Brønsted Acid and H-Bond Activation in Boronic Acid CatalysisChem. Eur. J. 2020, 26, 9883-98888 (invited manuscript for the Young Investigators special issue). (green open access)


44. Preiner, M.; Igarashi, K.; Muchowska, K. B.; Yu, M.; Varma, S. J.; Kleinermanns, K.; Nobu, M. K.; Kamagata, Y.; Tüysüz, H.*; Moran, J.* Martin, W. F.* “A hydrogen dependent geochemical analogue of primordial carbon and energy metabolismNature Ecol. Evol. 2020, 4, 534-542 (free read-only link)(green open access)


43. Thomas, A.; Jayachandran, A.; Lethuillier-Karl, L.; Vergauwe, R. M. A.; Nagarajan, K.; Devaux, E.; Genet, C.; Moran, J.; Ebbesen, T. W. “Ground state chemistry under vibrational strong coupling: Dependence of thermodynamic parameters on the Rabi splitting energyNanophotonics  2020, 9, 249-255. (green open access)

42. Noël, F.; Yi, J.; Vuković, V. D.; Richmond, E.; Kravljanac, P.; Moran, J.* “Catalytic Synthesis of Trifluoromethylated Allenes, Indenes, Chromenes and Olefins from Propargylic Alcohols in HFIPJ. Org. Chem. 2019, 84, 15926-15947. (green open access)


41. Chatelain, P.; Sau, A.; Rowley, C. N.; Moran, J.* “Suzuki−Miyaura Coupling of (Hetero)Aryl Sulfones: Complementary Reactivity Enables Iterative Polyaryl SynthesisAngew. Chem. Int. Ed. 2019, 58, 14959-14963. (green open access)

  • Selected as a “Hot Paper”
  • Highlighted  in Synfacts 2019, 15, 1253
  • Formerly a pre-print on ChemRxiv

40. Muchowska, K. B.; Varma, S. J.; Moran, J.* “Synthesis and breakdown of universal metabolic precursors promoted by iron” Nature 2019, 569, 104-107. (free link)(green open access).

Nature TOC

39. Thomas, A.; Lethuillier-Karl, L.; Nagarajan, K.; Vergauwe, R. M. A.; George, J.; Chervy, T.; Shalabney, A.; Devaux, E.; Genet, C.; Moran, J.*; Ebbesen, T. W.* “Tilting a Ground State Reactivity Landscape by Vibrational Strong Coupling“. Science 2019, 363, 615-619. (green open access)

VSC image

38. Muchowska, K. B.*; Chevallot-Beroux, E.; Moran, J.* “Recreating ancient metabolic pathways before enzymesBioorganic Med. Chem. 2019, 27, 2292-2297 (invited account in honor of Raphael Rodriguez’s Tetrahedron Young Investigator Award). (green open access)

Graphical abstract v2

37. Chevallot-Beroux, E.; Ako, A. M.; Schmitt, W.; Twamley, B.; Moran, J., Boudon, C.; Ruhlmann, L.; Mameri, S.* “Synthesis of New Mn19 Analogues and their Structural, Electrochemical and Catalytic Properties”, Dalton Trans. 2019, 48, 4830-4836. (green open access)

36. Richmond, E.; Yi, J.; Vuković, V. D.; Sajadi, F.; Rowley, C. N.; Moran, J.* “Ring-opening hydroarylation of monosubstituted cyclopropanes enabled by hexafluoroisopropanolChem. Sci. 2018, 9, 6411 (gold open access).

TOC v2

35. Varma, S. J.; Muchowska, K. B.; Chatelain, P.; Moran, J.* “Native iron reduces CO2 to intermediates and end-products of the acetyl CoA pathwayNature Ecol. Evol. 2018, 2, 1019-1024 (free read-only link)(green open access).

WL graphic cropped

34. Richmond, E.; Vuković, V. D.; Moran, J.* “Nucleophilic Ring Opening of Donor-Acceptor Cyclopropanes Catalyzed by a Brønsted Acid in HexafluoroisopropanolOrg. Lett. 2018, 20, 574-577. (green open access)

Donor Acceptor TOC

33. Richmond, E.*; Moran, J.* “Recent Advances in Nickel Catalysis Enabled by Stoichiometric Metallic Reducing AgentsSynthesis 2018, 50, 499-513 (invited review). (green open access)


32. Dryzhakov, M.; Moran, J.* “Update on Borinic Acid. B,B-Bis(2,3,4,5,6-pentafluorophenyl) Encyclopedia of Reagents for Organic Synthesis 2018.

31. Muchowska, K. B.; Varma, S. J.; Chevallot-Beroux, E.; Lethuillier-Karl, L.; Li, G.; Moran, J.* “Metals promote sequences of the reverse Krebs cycleNature Ecol. Evol. 2017, 1, 1716-1721 (free read-only link)(green open access).

hurricane rTCa

30. Vuković, V. D.; Richmond, E.; Wolf, E.; Moran, J.* “Catalytic Friedel-Crafts Reactions of Highly Electronically Deactivated Benzylic AlcoholsAngew. Chem. Int. Ed. 2017, 56, 3085-3089 (green open access).toc-acs-white-background-copy

29. Dryzhakov, M.; Richmond, E.; Li, G.; Moran, J.* “Catalytic B(C6F5)3•H2O-Promoted Defluorinative Functionalization of Tertiary Aliphatic FluoridesJ. Fluor. Chem. 2017, 193, 45-51.toc

28. Richmond, E.; Moran, J.* “Harnessing Complex Mixtures for Catalyst DiscoverySynlett 2016, 27, 2637-2643 (invited Synpacts highlight article).

  • Selected as cover article (December 1, 2016)

27. Thomas, A.; George, A.; Shalabney, A.; Dryzhakov, M.; Varma, S. J.; Moran, J.; Chervy, T.; Zhong, X.; Devaux, E.; Genet, C.; Hutchison, J.; Ebbesen, T. W. “Ground state chemical reactivity under vibrational coupling to the vacuum fieldAngew. Chem. Int. Ed. 2016, 55, 11462-11466 (collaboration with Ebbesen group).

TOC graphic
  • Selected as Hot Paper.
  • Highlighted by “In the Pipeline” blog by Derek Lowe (Science Translational Medicine)

26. Haar, S.; Bruna, M.; Lian, J. X.; Tomarchio, F.; Olivier, Y.; Mazzaro, R.; Morandi, V.; Moran, J.; Ferrari, A.; Beljonne, D.; Ciesielski, A.; Samori, P. “Liquid Phase Exfoliation of Graphite with α-Functionalized AlkanesJ. Phys. Chem. Lett. 2016, 7, 2714-2721 (collaboration with Samori group).

25. Richmond, E.; Khan, I. U.; Moran, J.* “Enantioselective and Regiodivergent Functionalization of N-Allylcarbamates by Mechanistically Divergent MulticatalysisChem. Eur. J. 2016, 22, 12274-12277.


24. Dryzhakov, M.; Moran, J.* “Autocatalytic Friedel-Crafts Reactions of Tertiary Aliphatic Fluorides Initiated by B(C6F5)3•H2O ACS Catalysis 2016, 6, 3670-3673.TOC ACS larger

23. Dryzhakov, M.; Richmond, E..; Moran, J.* “Recent Advances in Direct Catalytic Dehydrative Substitution of Alcohols” Synthesis 201648 935-959 (invited review).TOC

  • Selected as cover article (April 1, 2016)

22. Dryzhakov, M.;‡ Hellal, M.;‡ Wolf, E.; Falk. F. C.; Moran, J.* “Nitro-Assisted Brønsted Acid Catalysis: Application to a Challenging Catalytic AzidationJ. Am. Chem. Soc. 2015, 137, 9555-9558. (‡These authors contributed equally).TOC Graphic v5

21. Richmond, E.; Moran, J.* “Ligand Control of E/Z Selectivity in Nickel Catalyzed Transfer Hydrogenative Alkyne Semi-ReductionJ. Org. Chem. 2015, 80, 6922-6929. Abstract TOC

20.  Wolf, E.; Richmond, E.; Moran, J.* “Identifying Lead Hits in Catalyst Discovery by Screening and Deconvoluting Complex Mixtures of Catalyst Components” Chem. Sci. 2015, 6, 2501-2505. (open access)TOC Graphic

19.  Hellal, M.; Falk, F. C.; Wolf, E.; Dryzhakov, M.; Moran, J.* “Breaking the Dichotomy of Reactivity vs Chemoselectivity in Catalytic SN1 Reactions of AlcoholsOrg. Biomol. Chem. 2014, 12, 5990-5994.TOC Graphic

Mentored Publications:

18.    Moran, J.; Krische, M. J. “Formation of C-C Bonds via Catalytic Hydrogenation and Transfer Hydrogenation” in Sustainable Catalysis; Hii, K. K. Ed., Wiley-VCH: Weinheim, 2013, Vol. 1.

17.    Moran, J.; Krische, M. J. “Enantioselective Carbonyl Allylation and Crotylation from the Alcohol Oxidation Level via C-C Bond Forming Transfer Hydrogenation” in Asymmetric Synthesis – The Essentials II; Christmann, M., Bräse, S., Eds, Wiley-VCH: Weinheim, 2012.

16.    Moran, J.; Krische, M. J. “Ruthenium-Catalyzed Formation of C-C Bonds via Transfer Hydrogenation” Pure Appl. Chem. 201284, 1729-1739 (Invited Review).

15. Legault, M.; McKay, C.; Moran, J. Lafreniere, M.; Pezacki, J.P. “Novel intramolecular cyclization and subsequent rearrangements of alkyne tethered N-heterocyclic carbenes”, Tetrahedron Lett. 2012, 53, 5663.

14.    MacDonald, M. J.; Schipper, D. J.; Ng, P.; Moran, J.; Beauchemin, A. M. “A Catalytic Tether Strategy: Simple Aldehydes Catalyze Intermolecular Alkene Hydroaminations J. Am. Chem. Soc. 2011133, 20100-20103.

13.    Moran, J.; Smith, A. G.; Carris, R.; Johnson, J. S.; Krische, M. J. “Polarity Inversion of Donor-Acceptor Cyclopropanes: Disubstituted δ-Lactones via Enantioselective Iridium Catalysis” J. Am. Chem. Soc. 2011133, 18618-18621.

12.    Zbieg, J. R.; Moran, J.; Krische, M. J. “Diastereo- and Enantioselective Ruthenium Catalyzed Hydrohydroxyalkylation of 2-Silyl-Butadienes: Carbonyl Syn-Crotylation from the Alcohol Oxidation Level”   J. Am. Chem. Soc. 2011133, 10582-10586.

11.    Moran, J.; Preetz, A.; Mesch, R. A.; Krische, M. J. “Iridium-catalysed direct C-C coupling of methanol and allenes” Nature Chem20113, 287-290.

10.    Moran, J.; McKay, C. S.; Pezacki, J. P. “Strain-Promoted 1,3-Dipolar Cycloadditions of Diazo Compounds with Cyclooctynes” Can. J. Chem. 2011, 89, 148-151 (Invited contribution in honour of Prof. J. C. Scaiano).

9.     McKay, C. S.; Moran, J.; Pezacki, J. P. “Nitrones as Dipoles for Rapid Strain-Promoted 1,3-Dipolar Cycloadditions with Cyclooctynes” Chem. Commun. 201046, 931-933.

8.     Moran, J.; Pfeiffer, J. Y.; Gorelsky, S. I.; Beauchemin, A. M. “Ketonitrones via Cope-Type Hydroamination of Allenes” Org. Lett. 200911, 1895-1898.

7.     Moran, J.; Dimitrijevic, E.; Lebrun, M.-E.; Bédard, A.-C.; Séguin, C.; Gorelsky, S. I.; Beauchemin, A. M. “Intermolecular Cope-Type Hydroamination of Alkenes and Alkynes using Hydroxylamines” J. Am. Chem. Soc. 2008130, 17893-17906.

6.     Cebrowski, P. H.; Roveda, J.-G.; Moran, J.; Gorelsky, S. I.; Beauchemin, A. M. “Metal-Free Intermolecular Hydroamination of Alkynes Using Hydrazines” Chem. Commun. 2008, 492-493.

5.     Beauchemin, A. M.; Moran, J.; Lebrun, M.-E.; Seguin, C.; Dimitrijevic, E.; Zhang, L.; Gorelsky, S. I. “Intermolecular Cope-Type Hydroamination of Alkenes and Alkynes” Angew. Chem. Int. Ed. 200847, 1410-1413.

4.     Moran, J.; Cebrowski, P. H.; Beauchemin, A. M. “Intermolecular Hydroaminations via Strained (E)-Cycloalkenes” J. Org. Chem. 200873, 1004-1007.

3.     Moran, J.; Dornan, P.; Beauchemin, A. M. “Strain-Release Electrophilic Activation via E-Cycloalkenones” Org. Lett. 20079, 3893-3896.

2.     Moran, J.; Suen, T.; Beauchemin, A. M. “Photoinduced 1,4-Additions of Indoles to Enones” J. Org. Chem200671, 676-679.

1.     Scott, S. L.; Church, T. L.; Nguyen, D. H.; Mader, E. A.; Moran, J. “An investigation of catalyst/cocatalyst/support interactions in silica-supported olefin polymerization catalysts based on Cp*TiMe3” Top. Catal.  200534, 109-120.