We are a young research group that is applying “systems” and supramolecular ways of thinking to solve problems in catalysis and the chemical origins of life.

1) Self-organized reaction networks to understand the origin of life


How did the self-organized chemistry that gave rise to life emerge before there were enzymes to act as catalysts? Why does biochemistry use the reactions and pathways that it does and not others? This ERC-funded project aims to understand the prebiotic origins of biological metabolism. We suspect that the metabolism underlying all living things started before the onset of Darwinian evolution as a self-organized reaction network that was driven into existence by a far-from-equilibrium environment, enabled by naturally occurring catalysts such as minerals and metal ions. To figure out the conditions that would have been required to initiate self-organization, we are searching for non-enzymatic versions of ancient, core metabolic processes. So far we have found non-enzymatic chemistry that resembles the acetyl CoA pathway [1,2], parts of the reverse Krebs cycle [3], the Krebs cycle and the glyoxylate cycle [4] and transamination to form ketoacids [5]. By developing non-enzymatic versions of other critical metabolic pathways (amino acid biosynthesis, gluconeogenesis, nucleotide biosynthesis, and missing parts of the reverse Krebs cycle) we expect to be able to triangulate the non-equilibrium conditions required to enable self-organization. We’ve recently reviewed the topic [6]. For an overview, see below for a talk from December 2020.

[1] Nat. Ecol. Evol. 2018, 2, 1019-1024. [2] Nat. Ecol. Evol. 2020, 4, 534-542.  [3] Nat. Ecol. Evol. 2017, 1, 1716-1721. [4] Nature 2019, 569, 104-107. [5] J. Am. Chem. Soc. 2021, online. [6] Chem. Rev. 2020, 120, 7708-7744.

2) Vibrational Strong Coupling for organic chemistry and catalysis

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This project aims to develop a completely new way to control the rate and selectivity of organic reactions: by selectively modifying relevant molecular vibrations by running the reaction between appropriately-spaced mirrors. Vibrational Strong Coupling (VSC) is an emerging field in the quantum optics community.  A collaboration between our group (organic chemistry) and the group of Prof. Thomas Ebbesen (a world leader in VSC), aims to exploit this phenomenon for use in organic synthesis and catalysis. Thus far, we have shown that VSC can be used to change the rates [1], chemoselectivity [2] and stereoselectivity [3] of ground state organic reactions. Ongoing work aims to understand and predict how VSC influences chemistry, to develop it as a tool for mechanistic insight, and to exploit it to streamline the outcomes of useful chemical transformations.

[1] Angew. Chem. Int. Ed. 2016, 55, 11462. [2] Science 2019, 363, 615. [3] Angew. Chem. Int. Ed. 2021, 60, 5712.

3) Development of Catalytic Synthetic Methodology 

We are broadly interested in the development of new catalytic methods for organic synthesis. Recent interests include specific solvent effects (particularly nitromethane and HFIP) on the direct nucleophilic substitution of alcohols [1], alkyl fluorides [2] and the ring opening of cyclopropanes [3]. We are also interested in extending the scope of cross-coupling reactions to include a broader range of functional groups [4].

[1] (a) Angew. Chem. Int. Ed. 2017, 56, 3085. (b)  J. Am. Chem. Soc. 2015, 137, 9555. (c) Chem 2021, in press. [2] ACS Catalysis 2016, 6, 3670. [3] (a) Org. Lett. 2018, 20, 574. (b) Chem. Sci. 20189, 6411. [4] (a) Angew. Chem. Int. Ed. 2019, 58, 14959. (b) Angew. Chem. Int. Ed. 2021, 60, in press.

 For more information on ongoing projects, please contact Dr. Moran directly.


Previous projects:

4) Catalyst discovery using complex mixtures – a systems approach


We have developed a simple algorithmic approach for screening and deconvoluting complex mixtures of catalyst components with the goal of rapidly identifying new catalysts and cooperative effects. We have used this strategy to uncover new organoboron [2] and nickel [2,3] catalysts, and have found that catalysts selected in this way tend to be useful in multicatalysis.[4] Our method has recently been implemented in workflows by major pharmaceutical companies.[5]

[1] For an account of our recent work in this area, see: Synlett 2016, 27, 2637. [2] Chem. Sci. 2015, 6, 2501. [3] J. Org. Chem. 2015, 80, 6922. [4] Chem. Eur. J. 2016, 22, 12274. [5] J. Org. Chem. 2021, 86, 1528.