Our paper on a large expansion of the Friedel-Crafts reaction has been accepted for publication in Chem. We describe Friedel-Crafts reactions with primary aliphatic alcohols and electronically deactivated epoxides, as well as sequential Friedel-Crafts reactions stemming from epoxide-opening, all without pre-activation. This was a massive project with over 170 examples, some of it reaching back nearly 4 years. Congrats to Shaofei, Marie, Florent, Vuk and Andrei and to our DFT collaborators in the Rowley lab (Carleton).
A warm welcome to Marie Vayer, who joins us from a prior postdoctoral appointment in Prof. Nuno Maulide’s group at the University of Vienna. Marie will work on the development of new synthetic methods exploiting HFIP. Welcome, Marie!